A legújabb módszerek iránt a diabétesz a gyermekek. Szurikáta Foglalkozás – mosolyt ad a szurik mellé! – Szurikáta Alapítvány


Novák: A figyelemfelkeltés is fontos a diabéteszesek segítéséhez

Genetics of type 1 diabetes in the Hungarian population Mission: To improve quality of life of children with diabetes Background Type 1 diabetes T1D is a complex disease caused by immune-mediated destruction of the pancreatic islets that develops in genetically susceptible individuals.

The disease process is initiated and maintained by environmental factors,that are poorly characterized. The genetic disease susceptibility is caused by combination of several predisposing gene variants.

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During the disease process, autoantibodies that develop against several self proteins, can be used as markers for disease prediction. They characterise partially different disease pathways, although this issue is very controversial nowadays.

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As the disease incidence is steadily increasing across Europe, studies to clarify genetic and immunologic factors for T1D are inevitable. Hungary is a medium incidence country app. Specific aims of the project 1.

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Association mapping of unknown T1D genes. To explore T1D genetic heterogeneity and define genetic patterns underlying alternative disease pathways.

To develop a highly sensitive and specific predictive genetic screening model for T1D in the Hungarian population.

Konfliktusmegoldási módszerek

Identification of genetic factors that control Beta-cell autoimmunity. Exploration of environmental factors that trigger Beta-cell autoimmunity.

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Strategy The first step in this project was to create a large population-based collection of T1D families that is fully representative for the Hungarian population. A network of 27 pediatric diabetes clinical centres was established in The area is covers the whole country and includes the five university pediatric departments, all the 17 county centres and a few local hospitals as well.

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These centres collect samples and clinical data from children with T1D and their family members. The target number of the project is collection of nuclear families.

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As a new development in the project the Immunogenomics Laboratory was established in Budapest, September oflocated at the 1st Department of Pediatrics, Semmelweis University. Highly qualified team ensures the expansion of the research activities.

Szurikáta Foglalkozás – mosolyt ad a szurik mellé! – Szurikáta Alapítvány

We launched our own new PhD program as well. Importantly, this improves early diagnosis, and provides better treatment results during the early phase after diagnosis.

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