The Impact Objective: Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type 1 diabetes in a longitudinal manner and to study the impact of age, gender, body mass index BMI and metabolic control.
Research design and methods: In this study, 88 children and adolescents with type 1 diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids.
Results: Serum adiponectin levels were significantly higher in children with type 1 diabetes compared with healthy children Adiponectin concentrations inversely correlated with BMI s.
No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Conclusions: Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children.