Diabetic macular edema diagnosis, Assessment of Biomarker Profile in Diabetic Macular Edema With Intravitreal Aflibercept Injection


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Advanced Eye Research Associates Rövid összefoglaló To assess the biomarker profile in diabetic macular edema patients in response to intravitreal aflibercept injection. Patients with legjobb ételek cukorbetegeknek macular edema who meet study requirements will receive monthly intravitreal injections of aflibercept as approved by FDA for a period of 6 months.

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A small quantity of fluid will be removed from the vitreous at each injection for laboratory evaluation of biomarkers present before, during and after treatment with aflibercept. Részletes leírás Study objective is to better understand the pathophysiology of diabetic macular edema DME by defining the factors that participate in the disease process or may be good biomarkers for disease progression. Study will investigate the temporal relationship between the course of treatment with anti-VEGF therapy and levels of candidate biomarkers previously identified to determine diabetic macular edema diagnosis biomarkers are affected by anti-VEGF therapy with aflibercept.

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Study will correlate response to therapy to particular biomarkers and attempt to identify those associated with resistance to therapy for DME.

Biomarker data will be correlated with serial clinical evaluation of disease progression. At each visit aqueous humor will be collected and stored 6 samples per patient.

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At termination of study all specimens will be analyzed for biomarkers identified from previous studies. Átfogó állapot.

DOI: Észlelés látásszázalék és célkitűzés: A Navilas® s mikropulzuslézerrel végzett kezelés biztonságosságának és hatásosságának vizsgálata diabeteses maculaoedemában. Módszer: Retrospektív vizsgálatunkba diabeteses maculaoedema miatt gondozott és legalább 6 hónapos utánkövetéssel rendelkező, korábban Navilas® s mikropulzuslézer-kezelésen átesett 28 beteg 46 szemét válogattuk be. Pórszász, Róbert Abstract: Retinal vein occlusion RVO is a leading cause of visual impairment across the globe, being the second most common vascular disease affecting the eye and threatening vision. The development of RVO is affected by a multitude of risk factors and pathomechanisms that result in vessel occlusion, macular edema, neovascularization and its complications. The diagnosis of RVO nowadays can be readily made Show more Retinal vein occlusion RVO is a leading cause of visual impairment across the globe, being the second most common vascular disease affecting the eye and threatening vision.